Yamaguchi, T., Samukawa, N., Matsumoto, S.m Shiota, M., Matsumoto, M., Nakao, R.m Hirayama, S., Yoshida, Y., Nishiyama, A., Ozeki, Y., Tomita, S.: BCG-derived acellular membrane vesicles elicit antimycobacterial immunity and innate immune memory. Front. Immunol,, 16(3): 1534615, 2025.

Takizawa, F., Domon, H., Hirayama, S., Isono, T., Sasagawa, K., Yonezawa, D., Ushida, A., Tsutsuura, S., Miyoshi, T., Mimuro, H., Yoshida, A., Tabeta, K., and Terao, Y.: Effective degradation of various bacterial toxins using ozone ultrafine bubble water. PLOS ONE, 19(7): e0306998, 2024.

Sirisereephap, K., Surboyo, MDC., Rosenkranz, AL., Terao, Y., Tabeta, K., Meada, T., Hajishengallis, G., and Maekawa, T.: Protocols for collecting mouse PDL cells and bone marrow cells, differentiation, and data analysis. STAR Protocols, 5(3): 103162, 2024.

Takahara, M., Hirayama, S., Futamata, H., Nakao, R., and Tashiro, Y.: Biofilm-derived membrane vesicles exhibit potent immunomodulatory activity in Pseudomonas aeruginosa PAO1. Microbiol. Immunol., 68(7): 224-236, 2024.

Saito, R., Domon, H., Hiyoshi, T., Hirayama, S., Maekawa, T., Takenaka, S., Noiri, Y., Ikeda, A., Hirose, T., Sunazuka, T., and Terao, Y.: A novel 12-membered ring non-antibiotic macrolide EM982 attenuates cytokine production by inhibiting IKKβ and IκBα phosphorylation., J. Biol. Chem., 300(6): 107384, 2024.

Domon, H., Hirayama, S., Isono, T., Saito, R., Yanagihara, K., and Terao, Y.: Lipoprotein signal peptidase-deficient Streptococcus pneumoniae exhibits impaired Toll-like receptor 2-stimulatory activity. Microbiol. Immunol., 68(4):155-159, 2024.

Sirisereephap, K., Tamura, H., Lim, JH., Surboyo, MDC., Isono, T., Hiyoshi, T., Rosenkranz, AL., Sato-Yamada, Y., Domon, H., Ikeda, A., Hirose, T., Sunazuka, T., Yoshiba, N., Okada, H., Terao, Y., Maeda, T., Tabeta, K., Chavakis, T., Hajishengallis, G., and Maekawa, T.: A novel macrolide-Del-1 axis to regenerate bone in old age. iScience, 27(2): 108798, 2024.

Isono, T., Hirayama, S., Domon, H., and Terao, Y.: Pneumococcus downregulates the molecular weight of the extracellular domain of the epidermal growth factor receptor of alveolar epithelial cells. Microbiol. Immunol., 68(1): 23-26, 2024.

Yasui, Y., Hirayama, S., Hiyoshi, T., Isono, T., Domon, H., Maekawa, T., Tabeta, K., and Terao, Y.: The pneumococcal protein SufC binds to host plasminogen and promotes its conversion to plasmin. Microorganisms, 11(12): 2969, 2023.

Nirei, J., Kobayashi, A., Habuka, R., Domon, H., Terao, Y., and Saitoh A.: Cord blood granulocyte colony-stimulating factor level as an optimal predictor of umbilical cord arteritis associated with brain injury at term equivalent age in preterm neonates. Cytokine, 171(11): 156369, 2023.

Domon, H., Hirayama, S., Isono, T., Sasagawa, K., Takizawa, F., Maekawa, T., Yanagihara, K., and Terao, Y.: Macrolides decrease the proinflammatory activity of macrolide-resistant Streptococcus pneumoniae. Microbiol. Spectr., 11(3): e00148-23, 2023.

Takenaka, S., Moro, H., Shimizu, U., Koizumi, T., Nagano, K., Edanami, N., Ohkura, N., Domon, H., Terao, Y., and Noiri, Y.: Preparing of point-of-care reagents for risk assessment in the elderly at home by a home-visit nurse and verification of their snalytical accuracy. Diagnostics, 13(14): 2407, 2023.

Nakao, R., Hirayama, S., Yamaguchi, T., Senpuku, H., Hasegawa, H., Suzuki, T., Akeda, Y., and Ohnishi, M.: A bivalent outer membrane vesicle-based intranasal vaccine to prevent infection of periodontopathic bacteria. Vaccine, 41(30): 4369-4383, 2023.

Isono, T., Hirayama, S., Domon, H., Maekawa, T., Tamura, H., Hiyoshi, T., Sirisereephap, K., Takenaka, S., Noiri, Y., and Terao, Y.: Degradation of EGFR on lung epithelial cells by neutrophil elastase contributes to the aggravation of pneumococcal pneumonia., J. Biol. Chem., 299(6): 104760, 2023.

Hirayama, S., Hiyoshi, T., Yasui, Y., Domon, H., and Terao, Y.: C-terminal lysine residue of pneumococcal triosephosphate isomerase contributes to its binding to host plasminogen. Microorganisms, 11(5): 1198, 2023.

Takizawa, F., Domon, H., Hiyoshi, T., Tamura, H., Shimizu, K., Maekawa, T., Tabeta, K., Ushida, A., and Terao, Y.: Ozone ultrafine bubble water exhibits bactericidal activity against pathogenic bacteria in the oral cavity and upper airway and disinfects contaminated healthcare equipment. PLOS ONE, 18(4): e0284115, 2023.

Tamura, H., Maekawa, T., Domon, H., Sirisereephap, K., Isono, T., Hirayama, S., Hiyoshi, T., Sasagawa, K., Takizawa, F., Maeda, T., Terao, Y., and Tabeta, K.: Erythromycin restores osteoblast differentiation and osteogenesis suppressed by Porphyromonas gingivalis lipopolysaccharide. Pharmaceuticals, 16(2): 303, 2023.

Hirayama, S., Yasui, Y., Sasagawa, K., Domon, H., and Terao, Y.: Pneumococcal proteins ClpC and UvrC as novel host plasminogen binding factors. Microbiol. Immunol., 67(2): 99-104, 2023.

Nakao, R., Kobayashi, H., Iwabuchi, Y., Kawahara, K., Hirayama, S., Ramstedt, M., Sasaki, Y., Kataoka, M., Akeda, Y., Ohnishi, M.: A highly immunogenic vaccine platform against encapsulated pathogens using chimeric probiotic Escherichia coli membrane vesicles. NPJ Vaccines, 7: 153, 2022.

Ibano, N., Inada, E., Otake, S., Kiyokawa, Y., Sakata, K., Sato, M., Kubota, N., Noguchi, H., Iwase, Y., Murakami, T., Sawami, T., Kakihara, Y., Maeda, T., Terunuma, M., Terao, Y., and Saitoh, S.: The role of genetically modified human feeder cells in maintaining the integrity of primary cultured human deciduous dental pulp cells. J. Clin. Med., 11(20): 6087, 2022.

Mizuno, K., Maree, M., Nagamura, T., Koga, A., Hirayama, S., Furukawa, S., Tanaka, K., Morikawa, K.: Novel multicellular prokaryote discovered next to an underground stream. eLife, 11: e71920, 2022.

Hirayama, S., Domon, H., Hiyoshi, T., Isono, T., Tamura, H., Sasagawa, K., Takizawa, F., and Terao, Y.: Triosephosphate isomerase of Streptococcus pneumoniae is released extracellularly by autolysis and binds to host plasminogen to promote its activation. FEBS Open Bio, 12(6): 1206-1219, 2022.

Hiyoshi, T., Domon, H., Maekawa, T., Tamura, H., Isono, T., Hirayama, S., Sasagawa, K., Takizawa, F., Tabeta, K., and Terao, Y.: Neutrophil elastase aggravates periodontitis by disrupting gingival epithelial barrier via cleaving cell adhesion molecules. Scientific Reports, 12: 8159, 2022.

Sirisereephap, K., Maekawa, T., Tamura, H., Hiyoshi, T., Domon, H., Isono, T., Terao, Y., Maeda, T., and Tabeta, K.: Osteoimmunology in periodontitis: Local proteins and compounds to alleviate periodontitis. Int. J. Mol. Sci., 23(10): 5540, 2022.

Sasaki, Y., Hirayama, S., and Nakao, R.: Scanning electron microscopy of Escherichia coli encapsulated in a spacerized graphene sandwich. Microscopy, 71(3):175-180, 2022.

Sasagawa, K., Domon, H., Sakagami, R., Hirayama, S., Maekawa, T., Isono, T., Hiyoshi, T., Tamura, H., Takizawa, F., Fukushima, Y., Tabeta, K., and Terao, Y.: Matcha green tea exhibits bactericidal activity against Streptococcus pneumoniae and inhibits functional pneumolysin. Antibiotics, 10(12): 1550, 2021.

Domon, H., Isono, T., Hiyoshi, T., Tamura, H., Sasagawa, K., Maekawa, T., Hirayama, S., Yanagihara, K., and Terao, Y.: Clarithromycin inhibits pneumolysin production via downregulation of ply gene transcription despite autolysis activation. Microbiol. Spectr., 9(2): e00318-21, 2021.

Hirayama, S., and Nakao, R.: Glycine induction method – Effective production of immunoactive bacterial membrane vesicles with low endotoxin content. Methods Mol. Biol. (published by Springer Nature), 2022;2414: 207-226, 2021.

Tamura, H., Maekawa, T., Domon, H., Hiyoshi, T., Hirayama, S., Isono, T., Sasagawa, K., Yonezawa, D., Takahashi, N., Oda, M., Maeda, T., Tabeta, K., and Terao, Y.: Effects of erythromycin on osteoclasts and bone resorption via DEL-1 induction in mice. Antibiotics, 10(3): 312, 2021.

Domon, H., and Terao, Y.: The role of neutrophils and neutrophil elastase in pneumococcal pneumonia. Front. Cell. Infect. Microbiol., March Vol. 11, Article 615959, eCollection, 2021.

Domon, H., Maekawa, T., Isono, T., Furuta, K., Kaito, C., and Terao, Y.: Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia. Scientific Reports, 11: 2432, 2021.

Matsugishi, A., Aoki-Nonaka, Y., Yokoji-Takeuchi, M., Yamada-Hara, M., Mikami, M., Hayatsu, M., Terao, Y., Domon, H., Taniguchi, M., Takahashi, N., Yamazaki, K., and Tabeta, K.: Rice peptide with amino acid substitution inhibits biofilm formation by Porphyromonas gingivalis and Fusobacterium nucleatum. Arch. Oral Biol., 121(1): 104956, 2021.

Macleod, T., Ainscough, JS., Hesse, C., Konzok, S., Braun, A., Buhl, A., Wenzel, J., Bowyer, P., Terao, Y., Herrick, S., Wittmann, M., and Stacey, M.: The proinflammatory cytokine IL-36γ is a global discriminator of harmless microbes and invasive pathogens within epithelial tissues. Cell Rep., 33(11): 108515, 2020.

Isono, T., Domon, H., Nagai, K., Maekawa, T., Tamura, H., Hiyoshi, T., Yanagihara, K., Kunitomo, E., Takenaka, S., Noiri, Y., and Terao, Y.: Treatment of severe pneumonia by hinokitiol in a murine antibiotic-resistant pneumococcal pneumonia model. PLOS ONE, 15(10): e0240329, 2020.

Tamura, H., Maekawa, T., Hiyoshi, T., and Terao, Y.: Animal model of periodontitis ― Analysis of experimental ligature-induced periodontitis model in mice ―. Methods Mol. Biol.: Periodontal Pathogens (published by Springer Nature), 2021;2210: 237-250, 2020.

Hasegawa, T., Takenaka, S., Oda, M., Domon, H., Hiyoshi, T., Sasagawa, K., Ohsumi, T., Hayashi, N., Okamoto, Y., Yamamoto, H., Ohshima, H., Terao, Y., and Noiri, Y.: Sulfated vizantin causes detachment of biofilms composed mainly of the genus Streptococcus without affecting bacterial growth and viability. BMC Microbiol., 20: 361, 2020.

Hirayama, S., and Nakao, R.: Intranasal vaccine study using Porphyromonas gingivalis membrane vesicles: Isolation method and application to a mouse model. Methods Mol. Biol.: Periodontal Pathogens (published by Springer Nature), 2021;2210: 157-166, 2020.

Maekawa, T., Tamura, H., Domon, H., Hiyoshi, T., Isono, T., Yonezawa, D., Hayashi, N., Takahashi, N., Tabeta, K., Maeda, T., Oda, M., Ziogas, A., Alexaki, VI., Chavakis, T., Terao, Y., and Hajishengallis, G.: Erythromycin inhibits neutrophilic inflammation and mucosal disease by upregulating DEL-1. JCI Insight, 5(15): e136706, 2020.

Habuka, R., Aizawa, Y., Izumita, R., Domon, H., Terao, Y., Takihara, H., Okuda, S., and Saitoh, A.: Innate immune responses in serum and cerebrospinal fluid from neonates and infants infected with parechovirus-A3 or enteroviruses. J. Infect. Dis., 222(4): 681-689, 2020.

Oda, M., Kurosawa, M., Yamamoto, H., Domon, H., Takenaka, S., Osumi, T., Maekawa, T., Yamasaki, N., and Terao, Y.: Sulfated vizantin inhibits biofilm maturation by Streptococcus mutans. Microbiol. Immunol., 64(7): 493-501, 2020.

Hirayama, S., and Nakao, R.: Glycine significantly enhances bacterial membrane vesicle production: a powerful approach for isolation of LPS-reduced membrane vesicles of probiotic Escherichia coli. Microb. Biotechnol., 13(4): 1162-1178, 2020.

Nakamura, T., Iwabuchi, Y., Hirayama, S., Narisawa, N., Takenaga, F., Nakao, R., and Senpuku, H.: Roles of membrane vesicles from Streptococcus mutans for the induction of antibodies to glucosyltransferase in mucosal immunity., Microb. Pathog., 149(12): 104260, 2020.

Ohsumi, T., Takenaka, S., Sakaue, Y., Suzuki, Y., Nagata, R., Hasegawa, T., Ohshima, H., Terao, Y., and Noiri, Y.: Adjunct use of mouth rinses with a sonic toothbrush accelerates the detachment of a Streptococcus mutans biofilm: an in vitro study. BMC Oral Health, 20: 161, 2020.

Hiyoshi, T., Domon, H., Maekawa, T., Yonezawa, D., Kunitomo, E., Tabeta, K., and Terao, Y.: Protective effect of hinokitiol against periodontal bone loss in ligature induced experimental periodontitis in mice. Arch. Oral Biol., 112(4): 104679, 2020.

Suzuki, Y., Ohsumi, T., Isono, T., Nagata, R., Hasegawa, T., Takenaka, S., Terao, Y., and Noiri, Y.: Effects of sub-minimum inhibitory concentration of chlorhexidine gluconate on development of in vitro multi-species biofilms. Biofouling, 36(2): 146-158, 2020.

Ziogas, A., Maekawa, T., Wiessner, RJ., Le, TT., Sprott, D., Troullinaki, M., Neuwirth, A., Anastasopoulou, V., Grossklaus, S., Chung, K., Sperandio, M., Chavakis, T., Hajishengallis, G., and Alexaki, VI.: DHEA inhibits leukocyte recruitment through regulation of the integrin antagonist Del-1. J. Immunol., 204(5): 1214-1224, 2020.

Hasegawa, T., Takenaka, S., Ohsumi, T., Ida, T., Ohshima, H., Terao, Y., Traithawit, N., Maeda, T., and Noiri, Y.: Effect of a novel glass ionomer cement containing flour-zinc-silicate fillers on biofilm formation and dentin ion incorporation. Clin. Oral Investig., 24(2): 963–970, 2020.

Domon, H., Hiyoshi, T., Maekawa, T., Yonezawa, D., Tamura, H., Kawabata, S., Yanagihara, K., Kimura, O., Kunitomo, E., and Terao, Y.: Antibacterial activity of hinokitiol against both antibiotic-resistant and -susceptible pathogenic bacteria predominant in the oral cavity and upper airways. Microbiol. Immunol., 63: 213-222, 2019.

Hiyoshi, T., Domon, H., Maekawa, T., Nagai, K., Tamura, H., Takahashi, N., Yonezawa, D., Miyoshi, T., Yoshida, A., Tabeta, K., and Terao, Y.: Aggregatibacter actinomycetemcomitans induces detachment and death of human gingival epithelial cells and fibroblasts via elastase release following leukotoxin-dependent neutrophil lysis. Microbiol. Immunol., 63: 100-110, 2019.

Nagai, K., Kimura, O., Domon, H., Maekawa, T., Yonezawa, D., and Terao, Y.: Antimicrobial susceptibility of Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis clinical isolates from children with acute otitis media in Japan from 2014 to 2017. J. Infect. Chemother., 25(3): 229-232, 2019.

Tamura, H., Maekawa, T., Domon, H., Hiyoshi, T., Yonezawa, D., Nagai, K., Ochiai, A., Taniguchi, M., Tabeta, K., Maeda, T., and Terao, Y.: Peptides from rice endosperm protein restrain periodontal bone loss in mouse model of periodontitis. Arch. Oral Biol., 98: 132-139, 2019.

Nagai, K., Domon, H., Maekawa, T., Hiyoshi, T., Tamura, H., Yonezawa, D., Habuka, R., Saitoh, A., and Terao, Y.: Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection. Vaccine, 37: 160-168, 2019.

Yamaguchi, M., Hirose, Y., Takemura, M., Ono, M., Sumitomo, T., Nakata, M., Terao, Y., and Kawabata, S.: Streptococcus pneumoniae evades host cell phagocytosis and limits host mortality through its cell wall anchoring protein PfbA. Front. Cell. Infect. Microbiol., August Vol. 9, Article 301, eCollection, 2019.

Soda, M., Saitoh, I., Murakami, T., Inada, E., Iwase, Y., Noguchi, H., Shibasaki, S., Kurosawa, M., Sawami, T., Terunuma, M., Kubota, N., Terao, Y., Ohshima, H., Hayasaki, H., and Sato, M.: Repeated human deciduous tooth-derived dental pulp cell reprogramming factor transfection yields multipotent intermediate cells with enhanced iPS cell formation capability. Scientific Reports, 9: 1490, 2019.

Aoki-Nonaka, Y., Tabeta, K., Yokoji, M., Matsugishi, A., Matsuda, Y., Takahashi, N., Sulijaya, B., Domon, H., Terao, Y., Taniguchi, M., and Yamazaki, K.: The AmyI‐1‐18 peptide derived from rice inhibits alveolar bone resorption via suppression of inflammatory cytokine production induced by lipopolysaccharide and interleukin‐1β in mice. J. Periodontol., 90(10):1160-1169, 2019.

Hasegawa, T., Takenaka, S., Wakamatsu, R., Ohsumi, T., Domon, H., Ohshima, H., Terao, Y., and Noiri, Y.: A horizontal sequential cutting method to estimate the effectiveness of dentin disinfection by using confocal laser scanning microscopy. J Endod., 45: 1142–1147, 2019.

Senpuku, H, Nakamura, T., Iwabuchi, Y., Hirayama, S., Nakao, R., and Ohnishi, M.: Effects of Complex DNA and MVs with GTF Extracted from Streptococcus mutans on the Oral Biofilm. Molecules, 24(17): 313, 2019.

Domon, H., Maekawa, T., Yonezawa, D., Nagai, K., Oda, M., Yanagihara, K., and Terao, Y.: Mechanism of macrolide-induced inhibition of pneumolysin release involves impairment of autolysin release in macrolide-resistant Streptococcus pneumoniae. Antimicrob. Agents Chemother., 62(11): e00161-18, 2018.

Kurosawa, M., Oda, M., Domon, H., Isono, T., Nakamura, Y., Saitoh, I., Hayasaki, H., Yamaguchi, M., Kawabata, S., and Terao, Y.: Streptococcus pyogenes CAMP factor promotes calcium ion uptake in RAW264.7 cells. Microbiol. Immunol., 62: 617-623, 2018.

Domon, H., Nagai, K., Maekawa, T., Oda, M., Yonezawa, D., Takeda, W., Hiyoshi, T., Tamura, H., Yamaguchi, M., Kawabata, S., and Terao, Y.: Neutrophil elastase subverts the immune response by cleaving toll-like receptors and cytokines in pneumococcal pneumonia. Front. Immunol., April Vol. 9, Article 732, eCollection, 2018.

Oda, M., Kurosawa, M., Yamamoto, H., Domon, H., Kimura, T., Isono, T., Maekawa, T., Hayashi, N., Yamada, N., Furue, Y., Kai, D., and Terao, Y.: Sulfated vizantin induces the formation of macrophage extracellular traps. Microbiol. Immunol., 62: 310-316, 2018.

Sakaue, Y., Takenaka, S., Ohsumi, T., Domon, H., Terao, Y., and Noiri, Y.: The effect of chlorhexidine on dental calculus formation: an in vitro study. BMC Oral Health, 18: 52, 2018.

Sumitomo, T., Mori, Y., Nakamura, Y., Honda-Ogawa, M., Nakagawa, S., Yamaguchi, M., Matsue, H., Terao, Y., Nakata, M., and Kawabata, S.: Streptococcal cysteine protease-mediated cleavage of desmogleins is involved in the pathogenesis of cutaneous infection. Front. Cell. Infect. Microbiol., January Vol. 8, Article 10, eCollection, 2018.

Nagai, K., Domon, H., Maekawa, T., Oda, M., Hiyoshi, T., Tamura, H., Yonezawa, D., Arai, Y., Yokoji, M., Tabeta, K., Habuka, R., Saitoh, A., Yamaguchi, M., Kawabata, S., and Terao, Y. : Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4. Cell. Immunol., 325: 14-22, 2018.

Kurosawa, M., Oda, M., Domon, H., Isono, T., Nakamura, Y., Saitoh, I., Hayasaki, H., Yamaguchi, M., Kawabata, S., and Terao, Y.: Streptococcus pyogenes CAMP factor promotes bacterial adhesion and invasion in pharyngeal epithelial cells without serum via PI3K/Akt signaling pathway. Microb. Infect., 20: 9-18, 2018.

Mitroulis, I., Chen, L. S., Singh, R. P., Kourtzelis, I., Economopoulou, M., Kajikawa, T., Troullinaki, M., Ziogas, A., Ruppova, K., Hosur, K., Maekawa, T., Wang, B., Subramanian, P., Tonn, T., Verginis, P., von Bonin, M., Wobus, M., Bornhäuser, M., Grinenko, T., Di Scala, M., Hidalgo, A., Wielockx, B., Hajishengallis, G., and Chavakis, T.: Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche. J. Clin. Invest., 127: 3624-3639, 2017.

Oda, M., Domon, H., Kurosawa, M., Isono, T., Maekawa, T., Yamaguchi, M., Kawabata, S., and Terao, Y.: Streptococcus pyogenes phospholipase A2 induces the expression of adhesion molecules on human umbilical vein endothelial cells and aorta of mice. Front. Cell. Infect. Microbiol., June Vol. 7, Article 300, eCollection, 2017.

Kajikawa, T., Meshikhes, F., Maekawa, T., Hajishengallis, E., Hosur, K. B., Abe, T., Moss, K., Chavakis, T., and Hajishengallis, G.: Milk fat globule epidermal growth factor 8 inhibits periodontitis in non-human primates and its gingival crevicular fluid levels can differentiate periodontal health from disease in humans. J. Clin. Periodontol., 44: 472-483, 2017.

Maekawa, T., Kulwattanaporn, P., Hosur, K., Domon, H., Oda, M., Terao, Y., Maeda, T., and Hajishengallis, G.: Differential expression and roles of secreted frizzled-related protein 5 (Sfrp5) and the wingless homolog Wnt5a in periodontitis. J. Dent. Res., 96: 571-577, 2017.

Murakami, T., Saitoh, I., Sato, M., Inada, E., Soda, M., Oda, M., Domon, H., Iwase, Y., Sawami, T., Matsueda, K., Terao, Y., Ohshima, H., Noguchi, H., and Hayasaki, H.: Isolation and characterization of lymphoid enhancer factor-1-positive deciduous dental pulp stem-like cells after transfection with a piggyBac vector containing LEF1 promoter-driven selection markers. Arch. Oral Biol. 81: 110-120, 2017.

Nagai, K., Domon, H., Oda, M., Shirai, T., Ohsumi, T., Terao, Y., and Arai, Y.: Antimicrobial activity of ethylene-vinyl acetate containing bioactive filler against oral bacteria. Dental Materials Journal, 480:173-179, 2016.

Domon, H., Oda, M., Maekawa, T., Nagai, K., Takeda, W., and Terao, Y.: Streptococcus pneumoniae disrupts pulmonary immune defence via elastase release following pneumolysin-dependent neutrophil lysis. Scientific Reports, 6: 38013, 2016.

Takenaka, S., Oda, M., Domon, H., Ohsumi, T., Suzuki, Y., Ohshima, H., Yamamoto, H., Terao, Y., and Noiri, Y.: Vizantin inhibits bacterial adhesion without affecting bacterial growth and causes Streptococcus mutans biofilm to detach by altering its internal architecture. Biochem. Biophys. Res. Commun., 480: 173-179, 2016.

Yamamoto, H., Oda, M., Kanno, M., Tamashiro, S., Tamura, I., Yoneda, T., Yamasaki, N., Domon, H., Nakano M., Takahashi, H., Terao, Y., Kasai, Y., and Imagawa, H.: Chemical hybridization of Vizantin and Lipid A to generate a novel LPS antagonist. Chem. Pham. Bull., 64: 246-257, 2016.

Sakaue, Y., Domon, H., Oda, M., Takenaka, S., Kubo, M., Fukuyama, Y., Okiji, T., and Terao, Y.: Anti-biofilm and bactericidal effects of Magnolia bark-derived magnolol and honokiol on Streptococcus mutans. Microbiol. Immunol., 60:10-16, 2016.

Kurosawa, M., Oda, M., Domon, H., Saitoh, I., Hayasaki, H., and Terao, Y.: Streptococcus pyogenes CAMP factor attenuates phagocytic activity of RAW 264.7 cells. Microb. Infect., 18: 118-127, 2016.

Domon, H., Uehara, Y., Oda, M., Seo, H., Kubota, N., and Terao, Y.: Poor survival of Methicillin-resistant Staphylococcus aureus on inanimate objects in the public spaces. MicrobiologyOpen, 5: 39-346, 2016.

Maekawa, T., Briones, R. A., Resuello, R. R., Kajikawa, T., Lambris, J. D., and Hajishengallis, G.: Inhibition of pre-existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3. J. Clin. Periodontol., 43: 238-49, 2016.

Kubo, M., Nishikawa, Y., Harada, K., Oda, M., Huang, JM., Domon, H., Terao, Y., and Fukuyama, Y.: Tetranorsesquiterpenoids and santalane-type sesquiterpenoids from Illicium lanceolatum and their antimicrobial activity against the oral pathogen Porphyromonas gingivalis. J. Nat. Prod., 78: 1466-1469, 2015.

Takagishi, T., Oda, M., Kabura, M., Kurosawa, M., Tominaga, K., Urano, S., Ueda, Y.,Kobayashi, K., Kobayashi, T., Sakurai, J., Terao, Y., and Nagahama, M.: Clostridium perfringens alpha-toxin induces GM1a clustering and TrkA phosphorylation in the host cell membrane. PLoS one, 10; e0120497, 2015.

Maekawa, T., Hosur, K., Abe, T., Kantarci, A., Van Dyke, TE., Chavakis, T., and Hajishengallis, G.: Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway. Nature Commun., 6:8272, doi: 10.1038/ncomms9272, 2015.

Shin, J., Maekawa, T., Abe, T., Hajishengallis, E., Hosur, K., Chavakis, T., and Hajishengallis, G.: The homeostatic factor Del-1 restrains osteoclastogenesis and inhibits bone loss in non-human primates. Science Transl. Med., 7(307): 307ra155, doi: 10.1126/scitranslmed.aac5380, 2015.

Hajishengallis, G., Maekawa, T., Abe, T., Hajishengallis, E., and Lambris, J. D.: Complement Involvement in Periodontitis: Molecular mechanisms and rational therapeutic approaches. Adv. Exp. Med. Biol., 865: 57-74, 2015.

Abe, T., AlSarhan, M., Benakanakere, M. R., Maekawa, T., Kinane, D. F., Cancro, M. P., Korostoff, J. M., and Hajishengallis, G.: The B cell-stimulatory cytokines BLyS and APRIL are elevated in human periodontitis and are required for B cell-dependent bone loss in experimental murine periodontitis. J. Immunol., 195:1427-35, 2015.

Ohsumi, T., Takenaka, S., Wakamatsu, R., Sakaue, Y., Narisawa, N., Senpuku, H., Ohshima, H., Terao, Y., and Okiji, T.: Residual structure of Streptococcus mutans biofilm following complete disinfection favors secondary bacterial adhesion and biofilm re-development. PLoS one, 10: e0116647, 2015.

Oda, M., Yamamoto, H., Shibutani, M., Nakano, M., Yabiku, K., Tarui, T., Kameyama, N., Shirakawa, D., Obayashi, S., Watanabe, N., Nakase, H., Suenaga, M., Matsunaga, Y., Nagahama, M., Takahashi, H., Imagawa, H., Kurosawa, M., Terao, Y., Nishizawa, M., and Sakurai, J.: Vizantin inhibits endotoxin-mediated immune responses via the Toll-like receptor 4/MD-2 complex. J. Immunol., 193: 4507-4514, 2014.

Domon, H., Nakajima, T., Tabeta, K., and Yamazaki, K.: Age-related alterations in gene expression of gingival fibroblasts stimulated with Porphyromonas gingivalis. J. Periodontal Res., 49: 536-543, 2014.

Aoki-Nonaka, Y., Nakajima, T., Miyauchi, S., Miyazawa, H., Yamada, H., Domon, H., Tabeta, K., and Yamazaki, K.: Natural killer T cells mediate alveolar bone resorption and a systemic inflammatory response in response to oral infection of mice with Porphyromonas gingivalis. J. Periodontal Res., 49: 69-76, 2014.

Maekawa, T., Krauss, J. L., Abe, T., Jotwani, R., Triantafilou, M., Triantafilou, K., Hashim, A., Hoch, S., Curtis, M. A., Nussbaum, G., Lambris, J. D., and Hajishengallis, G.: Proactive microbial manipulation of complement and Toll-like receptor signaling to promote dysbiosis by uncoupling bacterial clearance from inflammation. Cell Host Microbe., 15: 768-78, 2014.

Maekawa, T., Abe, T., Hajishengallis, E., Hosur, KB., DeAngelis, R., Ricklin, D., Lambris, J. D., and Hajishengallis, G.: Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis. J. Immunol., 192: 6020-6027, 2014.

Maekawa, T., and Hajishengallis, G.: Topical treatment with probiotic Lactobacillus brevis CD2 inhibits experimental periodontal inflammation and bone loss. J. Periodontal. Res., 49: 785-91, 2014.

Maekawa, T.: Investigation of Wnt5a and sFRP5 expressions in healthy and chronic periodontitis tissues. Niigata. Dent. J., 45: 21-28, 2014.

Wakamatsu, R., Takenaka, S., Ohsumi, T., Terao, Y., Ohshima, H., and Okiji, T.: Penetration kinetics of four mouthrinses into Streptococcus mutans biofilms analyzed by direct time-lapse visualization. Clin. Oral Invest., 8: 625-634, 2014.

Nohara, F., Nagaya, K., Asai, H., Tsuchida, E., Okamoto, T., Hayashi, T., Sakata, H., Terao, Y., and Azuma, H.: Neonatal pleural empyema caused by emm type 6 group A Streptococcus. Pediatirics International, 55: 519-521, 2013.

Murakami, T., Saitoh, I., Inada, E., Kurosawa, M., Iwase, Y., Noguchi, H., Terao, Y., Yamasaki, Y., Hayasaki, H., and Sato, M.: STO feeder cells are useful for propagation of primarily cultured human deciduous dental pulp cells in view of elimination of contaminated bacteria and promotion of cellular outgrowth. Cell Medicine, 6: 75-81, 2013.

Yamaguchi, M., Terao, Y.*, Mori-Yamaguchi, M., Domon, H., Sakaue, Y., Yagi, T., Nishino, K., Yamaguchi, A., Nizet, V., and Kawabata, S.: Streptococcus pneumoniae invades erythrocytes and utilizes them to evade human innate immunity. PLoS one, 8: e77282, 2013.

Honda-Ogawa, M., Ogawa, T., Terao, Y.*, Sumitomo, T., Nakata, M., Ikebe, K., Maeda, Y., and Kawabata, S.: Cysteine proteinase from Streptococcus pyogenes enables to evade innate immunity via degradation of complement factors. J. Biol. Chem., 288: 15854-15864, 2013.

Yamaguchi, M., Terao, Y., and Kawabata, S.: Pleiotropic virulence factor – Streptococcus pyogenes fibronectin-binding proteins. Cell. Microbiol., 15: 503-511, 2013.

Sumitomo, T., Nakata, M., Higashino, M., Terao, Y., and Kawabata, S.: Group A streptococcal cysteine protease cleaves epithelial junctions and contributes to bacterial translocation. J. Biol. Chem., 288: 13317-13324, 2013.

Okahashi, N., Nakata, M., Sumitomo, T., Terao, Y., and Kawabata, S.: Hydrogen peroxide produced by oral streptococci induces macrophage cell death. PLoS one, 8: e62563, 2013.

Ogawa, T., Terao, Y., Honda-Ogawa, M., Hashimoto, S., Ikebe, K., Maeda, Y., and Kawabata, S.: MicroRNA fragments derived from Streptococcus pyogenes enable activation of neutrophil phagocytosis: in vitro study. Microb. Infect., 15:212-218, 2013.

Hajishengallis, G., Maekawa, T., Abe, T., Hajishengallis, E., and Lambris, J. D.: Complement involvement in periodontitis: Mechanisms and therapeutic intervention. Molecular Immunology., 56: 265-7, 2013.

Hajishengallis, G., Abe, T., Maekawa, T., Hajishengallis, E., and Lambris, J. D.: Role of complement in host-microbe homeostasis of the periodontium. Semin. Immunol., 25: 65-72. 2013.

Murakami, J., Terao, Y., Morisaki, I., Hamada, S., and Kawabata, S.: Group A streptococcus adheres to pharyngeal epithelial cells with salivary proline-rich proteins via GrpE chaperone protein. J. Biol. Chem., 287: 22266-22275, 2012.

Mori, Y., Yamaguchi, M., Terao, Y.*, Hamada, S., Ooshima, T., and Kawabata, S.: α-enolase of Streptococcus pneumoniae induces formation of neutrophil extracellular traps. J. Biol. Chem., 287: 10472-10481, 2012.

Ogawa, T., Yamasaki, S., Honda, M., Terao, Y., Kawabata, S., and Maeda, Y.: Long-term survival of salivary streptococci on dental devices made of EVA. Int. J. Oral Science, 4:14-18, 2012.

Kimura, K. R., Nakata, M., Sumitomo, T., Kreikemeyer, B., Podbielski, A., Terao, Y., and Kawabata, S.: Involvement of T6 pili in biofilm formation by serotype M6 Streptococcus pyogenes. J. Bacteriol., 194: 804-812, 2012.

Sumitomo, T., Nakata, M., Yamaguchi, M., Terao, Y., and Kawabata S.: S-carboxymethylcysteine inhibits adherence of Streptococcus pneumoniae to human alveolar epithelial cells. J. Med. Microbiol., 61: 101-108, 2012.

Miyazawa, H., Tabeta, K., Miyauchi, S., Aoki-Nonaka, Y., Domon, H., Honda, T., Nakajima, T., and Yamazaki, K.: Effect of Porphyromonas gingivalis infection on post-transcriptional regulation of the low-density lipoprotein receptor in mice. Lipids Health Dis., 11:121, 2012.

Miyazawa, H., Honda, T., Miyauchi, S., Domon, H., Okui, T., Nakajima, T., Tabeta, K., and Yamazaki, K.: Increased serum PCSK9 concentrations are associated with periodontal infection but do not correlate with LDL cholesterol concentration. Clin. Chim. Acta, 413(1-2): 154-159, 2012.

Miyauch, S., Maekawa, T., Aoki, Y., Miyazawa, H., Tabeta, K., Nakajima, T., and Yamazaki, K.: Oral infection with Porphyromonas gingivalis and systemic cytokine profile in C57BL/6.KOR-ApoE shl mice. J. Periodontal. Res., 47: 402-8, 2012.

Miyashita, H., Honda, T., Maekawa, T., Takahashi, N., Aoki, Y., Nakajima, T., Tabeta, K., and Yamazaki, K.: Relationship between serum antibody titres to Porphyromonas gingivalis and hs-CRP levels as inflammatory markers of periodontitis. Arch. Oral. Biol., 57: 820-829, 2012.

Nakata, M., Kimura, K. R., Sumitomo, T., Wada, S., Sugauchi, A., Oki, E., Higashino, M., Kreikemeyer, B., Podbielski, A., Okahashi, N., Hamada, S., Isoda, R., Terao, Y., and Kawabata, S.: Assembly mechanism of FCT type 1 pili in serotype M6 Streptococcus pyogenes. J. Biol. Chem., 286: 37566-37577, 2011.

Okahashi, N., Okinaga T., Sakurai, A., Terao, Y., Nakata M. Nakashima K., Shintani S., Kawabata S., Ooshima T., and Nishihara T.: Streptococcus sanguinis induces foam cell formation and cell death of macrophages in association with production of reactive oxygen species. FEMS Microbiol. Lett., 323:164-170, 2011.

Hoshino, T., Kondo, Y., Saito, K., Terao, Y., Okahashi, N., Kawabata, S., and Fujiwara, T.: Novel epitopic region of glucosyltransferase B from Streptococcus mutans. Clin. Vaccine Immunol., 18:1552-1561, 2011.

Baatarjav, T., Kataoka, K., Gilbert, R. S., Terao, Y., Fukui, M., Goto, M., Kawabata, S., Yamamoto, M., Fujihashi, K., and Ito, H. O.: Mucosal immune features to phosphorylcholine by nasal Flt3 ligand cDNA-based vaccination. Vaccine, 79:2819-2828, 2011.

Ogawa, T., Terao, Y., Okuni, H., Ninomiya, K., Sakata, H., Ikebe, K., Maeda, Y., and Kawabata, S.: Biofilm formation or internalization into epithelial cells enable Streptococcus pyogenes to evade antibiotic eradication in patients with pharyngitis. Microb. Pathog., 51: 58-68, 2011.

Ogawa, T., Terao, Y., Sakata, H., Okuni, H., Ninomiya, K., Ikebe, K., Maeda, Y., and Kawabata, S.: Epidemiological characterization of Streptococcus pyogenes isolated from patients with multiple onsets of pharyngitis. FEMS Microbiol. Lett. 318: 143-151, 2011.

Kataoka,K., Fujihashi, K., Terao, Y., Gilbert, R. S., Sekine, S., Kobayashi, R., Fukuyama, Y., Kawabata, S., and Fujihashi, K. Oral-nasopharyngeal dendritic cells mediate T cell-independent IgA class switching on B-1 B cells. PLoS one, 6: e25396, 2011.

Okahashi, N., Nakata, M., Sakurai, A., Terao, Y., Hoshino, T., Yamaguchi, Y., Isoda, R., Sumitomo, T., Nakano, K., Kawabata, S., and Ooshima, T.: Pili of oral Streptococcus sanguinis bind to salivary amylase and promote the biofilm formation. Microb. Pathog., 50: 148-154, 2011.

Sumitomo, T., Nakata, M., Higashino, M., Jin Y., Terao, Y., Fujinaga, Y., and Kawabata, S. : Streptolysin S contributes to group A streptococcal translocation across an epithelial barrier. J. Biol. Chem., 286: 2750-2761, 2011.

Liang, S., Krauss, J.L., Domon, H., McIntosh, M. L., Hosur, K.B., Qu, H., Li, F., Tzekou, A., and Lambris, J.D., Hajishengallis, G.: The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss. J. Immunol., 186(2): 869-877, 2011.

Nakagaki, H., Sekine, S., Terao, Y., Toe, M., Tanaka, M., Shizukuishi, S., Ito, H., Kawabata, S., McGhee, J. R., Fujihashi, K., and Kataoka, K.: Fusobacterium nucleatum envelope protein, FomA, is immunogenic and binds to salivary statherin-derived peptide. Infect. Immun., 78: 1185-1192, 2010.

Okahashi, N., Nakata, M., Sakurai, A., Terao, Y., Hoshino, T., Yamaguchi, Y., Isoda, R., Sumitomo, T., Nakano, K., Kawabata, S., and Ooshima, T.: Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion. Biochem. Biophys. Res. Commun., 391:1192-1196, 2010.

Takahashi, N., Honda, T., Domon, H., Nakajima, T., Tabeta, K., and Yamazaki, K.: Interleukin-1 receptor-associated kinase-M in gingival epithelial cells attenuates the inflammatory response elicited by Porphyromonas gingivalis. J. Periodontal Res., 45(4): 512-519, 2010.

Nakajima, T., Honda, T., Domon, H., Okui, T., Kajita, K., Ito, H., Takahashi, N., Maekawa, T., Tabeta, K., and Yamazaki, K.: Periodontitis-associated up-regulation of systemic inflammatory mediator level may increase the risk of coronary heart disease. J. Periodontal Res., 45(1): 116-122, 2010.

Liang, S., Hosur, K.B., Domon, H., and Hajishengallis, G.: Periodontal inflammation and bone loss in aged mice. J. Periodontal Res., 45(4): 574-578, 2010.

Wang, M., Krauss, J. L., Domon, H., Hosur, K. B., Liang, S., Magotti, P., Triantafilou, M., Triantafilou, K., Lambris, J. D., and Hajishengallis G.: Microbial hijacking of complement-toll-like receptor crosstalk. Sci. Signal., 3(109):ra11, 2010.

Yamaguchi, M., Minamide, M., Terao, Y., Isoda, R., Ogawa, T., Yokota, S., Hamada, S., and Kawabata, S.: Nrc of Streptococcus pneumoniae suppresses capsule expression and enhances anti-phagocytosis. Biochem. Biophys. Res. Commun., 390: 155-160, 2009.

Terao, Y., Isoda, R., Murakami, J. Hamada, S., and Kawabata, S.: Molecular and biological characterization of novel gtf regulation-associated genes in Streptococcus mutans. Oral Microbiol. Immunol., 24: 211-217, 2009.

Nakata, M., Köller, T. , Moritz, K., Ribardo, D., Jonas, L., McIver, K. S., Sumitomo, T., Terao, Y., Kawabata, S., Podbielski, A., and Kreikemeyer, B.: Mode of expression and functional characterization of FCT-3 pilus region encoded proteins in the Streptococcus pyogenes serotype M49. Infect. Immun., 77: 32-44, 2009.

Wang, M., Liang, S., Hosur, K. B., Domon, H., Yoshimura, F., Amano, A., and Hajishengallis, G.: Differential virulence and innate immune interactions of Type I and II fimbrial genotypes of Porphyromonas gingivalis. Oral Microbiol. Immunol., 24(6): 478-484, 2009.

Liang, S., Domon, H., Hosur, K. B., Wang, M., and Hajishengallis, G.: Age-related alterations in innate immune receptor expression and ability of macrophages to respond to pathogen challenge in vitro. Mech. Ageing Dev., 130(8): 538-546, 2009.

Domon, H., Takahashi, N., Honda, T., Nakajima, T., Tabeta, K., Abiko, Y., and Yamazaki, K.: Up-regulation of the endoplasmic reticulum stress-response in periodontal disease. Clin. Chim. Acta, 401(1-2): 134-140, 2009.

Yamaguchi, M., Terao, Y., Hamada, S., and Kawabata, S.: PfbA, a novel plasmin- and fibronectin-binding protein of Streptococcus pneumoniae contributes to fibronectin-dependent adhesion and antiphagocytosis. J. Biol. Chem., 283: 36272-36279, 2008.

Okamoto, S., Terao, Y., Hasuike, K., Hamada, S., and Kawabata, S.: A novel streptococcal leucine zipper protein (Lzp) that binds to binds to human immunoglobulins. Biochem. Biophys. Res. Commun., 377: 1128-1134, 2008.

Terao, Y., Mori, Y., Yamaguchi, M., Shimizu, Y., Ooe, K., Hamada, S., and Kawabata S.: Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunity. J. Biol. Chem., 283: 6253-6260, 2008.

Kunitomo, E., Terao, Y., Okamoto, S., Rikimaru, T., Hamada, S., and Kawabata, S.: Molecular and biological characterization of histidine triad protein in group A streptococci. Microbes Infect., 10: 414-423, 2008.

Okamoto, S., Terao, Y., Tamura, Y., Hamada, S., and Kawabata, S.: Streptococcal immunoglobulin-binding protein Sib35 exerts stimulatory and mitogenic effects toward mouse B lymphocytes. FEMS Microbiol. Lett., 281: 73-80, 2008.

Itsuki, Y., Saeki, M., Nakahara, H., Egusa, H., Irie, Y., Terao, Y., Kawabata, S., Yatani, H., and Kamisaki, H.: Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domains. FEBS Lett., 582: 2365-2370, 2008.

Honda, T., Aoki, Y., Takahashi, N., Maekawa, T., Nakajima, T., Ito, H., Tabeta, K., Okui, T., Kajita, K., Domon, H., and Yamazaki, K.: Elevated expression of IL-17 and IL-12 genes in chronic inflammatory periodontal disease. Clin. Chim. Acta, 395(1-2): 137-141, 2008.

Domon, H., Honda, T., Oda, T., Yoshie, H., and Yamazaki, K.: Early and preferential induction of IL-1 receptor-associated kinase-M in THP-1 cells by LPS derived from Porphyromonas gingivalis. J. Leukoc. Biol., 83(3): 672-679, 2008.

Saeki, M., Irie, Y. Ni, L. Itsuki, Y. Terao, Y., Kawabata, S., and Kamisaki Y.: Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturation. J. Biol. Chem., 282: 11786-11794, 2007.

Okamaoto, S., Terao, Y., Kaminishi, H., Hamada, S., and Kawabata S.: Inflammatory immune responses by water-insoluble alpha-glucans. J. Dent. Res., 86, 242-248, 2007.

Kajita, K., Honda, T., Amanuma, R., Domon, H., Okui, T., Ito, H., Yoshie, H., Tabeta, K., Nakajima, T., and Yamazaki, K.: Quantitative messenger RNA expression of Toll-like receptors and interferon-alpha1 in gingivitis and periodontitis. Oral Microbiol. Immunol., 22(6): 398-402, 2007.

Yamazaki, K., Honda, T., Domon, H., Okui, T., Kajita, K., Amanuma, R., Kudoh, C., Takashiba, S., Kokeguchi, S., Nishimura, F., Kodama, M., Aizawa, Y., and Oda, H.: Relationship of periodontal infection to serum antibody levels to periodontopathic bacteria and inflammatory markers in periodontitis patients with coronary heart disease. Clin. Exp. Immunol., 149(3): 445-452, 2007.

Yamaguchi, M., Terao, Y., Ogawa, T., Takahashi, T., Hamada, S., and Kawabata S.: Role of Streptococcus sanguinis sortase A in bacterial colonization. Microbes Infect., 8: 2791-2796, 2006.

Terao, Y., Yamaguchi, M., Hamada, S., and Kawabata, S.: Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils. J. Biol. Chem., 281: 14215-14223, 2006.

Honda, T., Domon, H., Okui, T., Kajita, K., Amanuma, R., and Yamazaki, K.: Balance of inflammatory response in stable gingivitis and progressive periodontitis lesions. Clin. Exp. Immunol., 144(1): 35-40, 2006.

Terao, Y., Okamoto, S., Kataoka, K., Hamada, S., and Kawabata, S.: Protective immunity against Streptococcus pyogenes challenge in mice after immunization with fibronectin-binding protein. J. Infect. Dis., 192: 2081-2091, 2005.

Yoshida, M., Saeki, M., Itsuki, Y., Irie, Y., Terao, Y., Kawabata, S., Hamada, S., Niwa, H., and Kamisaki, Y.: Search for calcineurin B binding proteins by yeast two-hybrid system. J. Pharma. Sci., 97: 217, 2005.

Okamoto, S., Tamura, Y., Terao, Y., Hamada, S., and Kawabata, S.: Systemic immunization with streptococcal immunoglobulin-binding protein Sib35 induces protective immunity against group A Streptococcus challenge in mice. Vaccine., 23: 4852-4859, 2005.

Kaito, C., Kurokawa, K., Matsumoto, M., Terao, Y., Kawabata, S., Hamada, S., and Sekimizu, K.: Silkworm-pathogenic bacteria infection model for identification of novel virulence genes. Mol. Microbiol., 56: 934-944, 2005.

Okamoto, S., Kawabata, S., Terao, Y., Fujitaka, H., Okuno, Y., and Hamada, S.: The Streptococcus pyogenes capsule is required for adhesion of bacteria to virus-infected alveolar epithelial cells and lethal invasive bacterial-viral superinfection. Infect. Immun., 72: 6068-6075, 2004.

Terao, Y., Kawabata, S., Nakata, M., Nakagawa, I., and Hamada, S.: Molecular characterization of a novel fibronectin-binding protein of Streptococcus pyogenes associated with isolates from toxic shock-like syndrome patients. J. Biol. Chem., 277: 47428-47435, 2002.

Kawabata, S., Tamura, Y., Murakami, J., Terao, Y., Nakagawa, I., and Hamada, S.: A novel, anchorless streptococcal surface protein. Biochem. Biophys. Research., 296: 1329-1333, 2002.

Murakami, J., Kawabata, S., Terao, Y., Kikuchi, K., Totsuka, K., Tamaru, A., Katsukawa, C., Moriya, K., Nakagawa, I., Morisaki, I., and Hamada, S.: Distribution of emm genotypes and superantigen genes of Streptococcus pyogenes isolated in Japan from 1994 to 1999. Epidemiol. Infect., 128: 397-404, 2002.

Terao, Y., Kawabata, S., Kunitomo, E., Nakagawa, I., and Hamada, S.: A novel laminin-binding protein of Streptococcus pyogenes, Lbp, is involved in the adhesion to epithelial cells. Infect. Immun., 70: 993-997, 2002.

Terao, Y., Kawabata, S., Kunitomo, E., Murakami, J., Nakagawa, I., and Hamada, S.: Fba, a novel fibronectin-binding protein from Streptococcus pyogenes, promotes bacterial entry into epithelial cells, and the fba gene is positively transcribed under the Mga regulator. Mol. Microbiol., 42: 75-86, 2001.

Kawabata, S., Kunitomo, E., Terao, Y., Nakagawa, I., Kikuchi, K., Totsuka, K., and Hamada, S.: Systemic and mucosal immunization with fibronectin-binding protein FBP54 induce protective immune responses against Streptococcus pyogenes challenge. Infect Immun., 69: 924-930, 2001.

Kawabata, S., Terao, Y., Nakagawa, I., and Hamada, S.: Molecular cloning, sequence, and characterization of a novel streptococcal phosphoglycerate dehydrogenase gene. Oral Microbiol. Immunol., 15: 56-62, 2000.

Kawabata, S., Terao, Y., Fujiwara, T., Nakagawa, I., and Hamada, S.: Targeted salivary gland immunization with plasmid DNA elicits specific salivary immunoglobulin A and G and serum immunoglobulin G antibodies in mice. Infect. Immun., 67, 5863-5868, 1999.

Fujiwara, T., Terao, Y., Hoshino, T., Kawabata, S., Ooshima, T., Sobue, S., Kimura, S., and Hamada, S.: Molecular analyses of glucosyltransferase genes among strains of Streptococcus mutans. FEMS Microbiol. Lett., 161: 331-336, 1998.

Kawabata, S., Terao, Y., Andoh, A., and Hamada, S.: Nucleotide sequence and molecular characterization of a gene encoding GTP-binding protein from Streptococcus gordonii. FEMS Microbiol. Lett., 156: 211-216, 1997.

当社では、かねてよりSDGsへの取り組みを推進しており、2022年9月に新潟県より「新潟県SDGs推進建設企業」として登録されました。
この度、登録から２年を経過した、当社の取り組み状況を公表いたします。
今後とも、持続可能な社会の創造に向けて、引き続き取り組んで参ります。

令和5年度に完成した「R５吉田バイパス用地調査等業務（その２）」業務について、国土交通省北陸地方整備局より局長表彰（優良委託業務）、新潟国道事務所様より事務所長表彰（優良建設技術者）を頂きました！
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＜業務概要＞
本業務は、一般国道１１６号吉田バイパス事業に必要な土地等の取得等のための用地測量、権利調査を行う業務である。また、当該業務の調査範囲の農地において、圃場整備事業が予定されていることから、関係機関との調整及び農繁期を考慮した工程管理が必要であると共に、用地取得業務が円滑に進むよう地元及び土地所有者への慎重かつ丁寧な対応が求められる業務でもある。

＜選定理由＞
　本業務においては、境界立会前に土地改良区と公図・換地処分資料を基に、意思の疎通を十分に図り、農繁期（稲刈り）前までに境界立会、現地測量作業を完了させ、10月下旬に図面確認を実施し、関係者全員から了解が得られ、工期内に業務を完了させることが出来た。
　調査に当たっては、効率的な測量システムの活用、人為的な転記ミスが生じないようなシステムの構築があった他、関係者との良好な関係の構築を図るなど、業務に対する責任感が特に優れていると認められた。
　また、用地調査等業務に関して豊富な経験、高度な専門知識を有するベテランから女性及び若手の担当者まで、バランスの良い業務体制が敷かれ、各担当者からは精度の高い業務成果を収めようとする熱意が感じられた。その業務執行体制と取組姿勢は高く評価できる。

当社では、かねてよりSDGsへの取り組みを推進しており、2022年9月には新潟県より「新潟県SDGs推進建設企業」として登録されました。
この度、登録から１年が経過した事を契機として、当社の取り組み状況を公表いたします。
今後とも、持続可能な社会の創造に向けて、引き続き取り組んで参ります。

当社における、デジタル技術の活用及びＤＸ推進の取り組み状況について、公開いたします。
当社は、こうした方向性、戦略、実施体制に基づき、デジタル技術の活用及びＤＸの推進をしてまいります。

この度、当社のSDGsへの取り組みが評価され、新潟県より「新潟県SDGs推進建設企業」として登録されました。
今後とも、持続可能な社会の創造に向けて、引き続き取り組んで参ります。

この度、当社WEBサイトをリニューアル致しました。
雰囲気も刷新して、画面も見やすくなりました。
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あらためまして、よろしくお願いいたします。

当社のSDGsへの取り組みを掲載致しました。
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令和4年7月25日　国土交通省　北陸地方整備局　飯豊山系砂防事務所様より
「滝谷沢砂防堰堤群外用地調査等業務」に対し、優良業務表彰【事務所長表彰】を受賞しました。
優良業務等の表彰とは、業務目的を十分理解のうえ、調査・解析等の専門技術力、工程・品質等の管理技術力に優れ、的確な成果の取りまとめを行うとともに、課題解決に向けた積極的な取り組みがみられるなど、他の模範となる企業および技術者を表彰するものです。
この度の受賞を機に、今後とも技術の研鑽に励み、円滑な事業推進の一翼を担うことで社会に貢献できるよう取り組んで参ります。